Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis

A New Approach to Monitoring and Evaluation of Cecal Ligation and Puncture Sepsis Model

Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...

Cecal ligation and puncture induced sepsis

Purpose: Multiresistant and vancomycin resistant Enterococcus faecium (VRE) can cause serious infections in hospitalized patients with various co-morbid diseases. We investigated the course of VRE peritonitis after cecal ligation and puncture (CLP)-induced sepsis and compared this to sham operated mice. Methods: Mice were subjected to CLP or sham surgery. Forty-eight hours thereafter four group...

Protective effects of curcumin on hepatocytes in cecal ligation and puncture-induced sepsis in rats

We aim to observe the protective effects of curcumin in hepatocytes in septic rat. Sprague-Dawley rats were randomly divided into six groups of 20 rats each: sham group; model group; xuebijing group; low dose group (50 mg/kg), middle dose group (100 mg/kg) and high dose group (150 mg/kg). Another 60 rats were randomly divided into the six above-mentioned experimental groups of 10 rats each to d...

Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis

Myrrh has been used as an antibacterial and anti-inflammatory agent. However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood. Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses. Myrrh inhibited LPS-induced productions of inflammatory mediators...

Protective role of autophagy in mouse cecal ligation and puncture-induced sepsis model